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Genes’ effect on ageing depends on sex and age, mouse study finds


There have long been good reasons to suspect that an individual’s DNA shapes how they age and how long they live. But “it’s always been iffy as to whether there’s true genetic control of lifespan and longevity”, says Robert Williams, a geneticist at the University of Tennessee Health Science Center in Memphis. Now, in a study that looked at more than 3,600 genetically diverse mice, Williams and his colleagues have identified several parts of the genome that influence longevity. Some of these genetic effects differed between male and female mice — and some affected lifespan only in mice that reached a certain age.

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