Immunotherapy, treatments that reinvigorate immune cells’ anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.
MYCN is a gene associated with cell proliferation and growth, which is mutated in many types of cancer. Scientists at St. Jude Children’s Research Hospital studying high-risk neuroblastoma found that MYCN plays a role in modifying the cellular state, causing a positive feedback loop that leads to a faster progressing disease.
St. Jude Children’s Research Hospital investigators collaborated with a global group of acute pediatric critical illness experts to reach a consensus definition of the condition.
A team of UTHSC researchers has been awarded $924,000 from the Department of Defense for their work developing a new treatment for ovarian cancer. The project is a collaboration between the labs of Wei Li, PhD, distinguished professor of Pharmaceutical Sciences and director of the Drug Discovery Center in the College of Pharmacy, Junming Yue,… Read More
The Department of Health and Human Services has awarded a University of Tennessee Health Science Center professor’s efforts to improve health outcomes in children with, or at risk for, neurodevelopmental and related disabilities, including autism spectrum disorders. Toni Whitaker, MD, professor in the Department of Pediatrics and division chief for Developmental Pediatrics in the UTHSC… Read More
Immunologists at St. Jude Children’s Research Hospital have identified a biological pathway that selectively controls how key immune cells, called T follicular helper cells, mature into functional components of the immune system.
Studies of the microbiome in the human gut focus mainly on bacteria. Other microbes that are also present in the gut — viruses, protists, archaea and fungi — have been largely overlooked. New research in mice now points to a significant role for fungi in the intestine — the communities of molds and yeasts known… Read More
One of UTHSC’s data scientists is applying her extensive expertise in informatics to a national effort to leverage big data in the fight against COVID-19. Charisse Madlock-Brown, PhD, MLS, a faculty member in Health Informatics and Information Management at UTHSC, is a co-lead for one of the clinical domain teams of the National COVID Cohort… Read More
