St. Jude Researchers Develop Scalable Method for Analyzing Single-Cell Data
Researchers are continuously striving to unravel the complexities of human biology, and recent advancements have brought them closer to this goal.
Publisher: BioEngineer
‘Goldilocks’ binding strength determines anti-cancer T-cell efficacy and fate
Immunotherapy, treatments that reinvigorate immune cells’ anti-cancer activity or reprogram T cells to target cancer, has shown promise in treating leukemias but has not yet been realized in solid tumors.
Change in MYCN-driven cell state opens therapeutic window in high-risk neuroblastoma
MYCN is a gene associated with cell proliferation and growth, which is mutated in many types of cancer. Scientists at St. Jude Children’s Research Hospital studying high-risk neuroblastoma found that MYCN plays a role in modifying the cellular state, causing a positive feedback loop that leads to a faster progressing disease.
Acute pediatric critical illness definition enables global research
St. Jude Children’s Research Hospital investigators collaborated with a global group of acute pediatric critical illness experts to reach a consensus definition of the condition.
UTHSC research collaboration on new treatment for ovarian cancer receives national support
A team of UTHSC researchers has been awarded $924,000 from the Department of Defense for their work developing a new treatment for ovarian cancer. The project is a collaboration between the labs of Wei Li, PhD, distinguished professor of Pharmaceutical Sciences and director of the Drug Discovery Center in the College of Pharmacy, Junming Yue,… Read More
Toni Whitaker receives $3.1 million for UTHSC’s LEND program
The Department of Health and Human Services has awarded a University of Tennessee Health Science Center professor’s efforts to improve health outcomes in children with, or at risk for, neurodevelopmental and related disabilities, including autism spectrum disorders. Toni Whitaker, MD, professor in the Department of Pediatrics and division chief for Developmental Pediatrics in the UTHSC… Read More
Discovery shows how tuning the immune system may enhance vaccines and ease disease
Immunologists at St. Jude Children’s Research Hospital have identified a biological pathway that selectively controls how key immune cells, called T follicular helper cells, mature into functional components of the immune system.
The gut mycobiome influences the metabolism of processed foods
Studies of the microbiome in the human gut focus mainly on bacteria. Other microbes that are also present in the gut — viruses, protists, archaea and fungi — have been largely overlooked. New research in mice now points to a significant role for fungi in the intestine — the communities of molds and yeasts known… Read More