Please join us for a ZOOM Seminar featuring
Dr. Daniele Caprioli
April 24, 2024 (12:00pm – 1:00pm)
Seminar Title:
Heroin pharmacokinetics and its impact on self-administration, relapse and sociability
Summary of Presentation:
Drug users instrumentalize the dose-time relationship to produce their desired effects (i.e. euphoria, withdrawal avoidance, etc.). This is achieved by harnessing drug type, dosage, route, and frequency of drug-taking. Yet, preclinical addiction research often employs self-administration and choice procedures based on discrete, as opposed to continuous dimension strategies, featured by pre-selected experimenter-imposed unit-doses spaced by timeouts. This approach imposes constraints on the voluntariness on the dose-time relationship and associated effects in rodents. This talk concerns the refinement of animal models of drug addiction and is grounded on strict pharmacokinetics and pharmacodynamics analysis of the drugs being investigated. The ambition is to guide preclinical researchers toward the optimal self-administration procedure for neuropharmacological studies, tailored to the specific drug being investigated and is largely motivated by the limited advancements in available treatment options stemming from preclinical insights.
Sponsor: Dr. Brendan Tunstall