A recently published article in Experimental Biology and Medicine (Volume 247, Issue 17, September, 2022) improves our understanding of pain phenotypes in sickle cell disease. The study, led by Dr. Keesha Powell-Roach in the College of Nursing at the University of Tennessee Health Science Center (Tennessee, USA), describes how catecholamine-O-methyltransferase (COMT) and dopamine receptor D3 (DRD3) haplotypes are associated with pain-related sickle cell disease features and acute care utilization.
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