A local DNA biorepository initiative has grown into one of the largest in the world for children. And now, a partnership with a New York-based pharma firm shows potential in unlocking DNA for research — and, in the future, personalized medicine. In 2015, the University of Tennessee Health Science Center (UTHSC) and Le Bonheur Children’s Hospital launched the Biorepository and Integrative Genomics (BIG) Initiative.