Tuesday, January 11, 2022 at 2:00 PM
Assistant Professor Candidate Guest Speaker:
Dr. Shijie Liu, PhD
Research Scientist, Texas Heart Institute
Baylor College of Medicine
“New Insights of Hippo Pathway in Heart Regeneration”
Heart Failure (HF) which caused by cardiomyocyte (CM) loss and pump dysfunction is a leading cause of death in the United States. HF results most commonly from ischemic heart disease secondary to coronary vascular disease. Treatments such as heart transplantation and ventricular assist device implantation are invasive and morbid and new approaches are required. Recent research efforts have revealed therapies based on endogenous CM self-renewal provide a tremendous opportunity to treat HF by directly inducing CM renewal. The Hippo signaling pathway, a serine threonine kinase cascade, is a highly conserved pathway that phosphorylated and suppress the activity of its key effector YAP/TAZ. In the heart, the Hippo pathway inhibits adult CM renewal and is considered to be a therapeutic target to treat HF. Our highly significant goal is to uncover molecular genetic mechanisms that can be used to increase endogenous CM renewal to aid in repairing the heart. In this presentation, I will update our recent findings regarding Hippo pathway in heart regeneration, including the translational potential of Hippo pathway in a pig model of myocardial infarction; Hippo pathway mediating noncanonical Wnt signaling in CM to cardiac fibroblast communication and fibrosis; and metabolism regulates YAP acetylation in heart regeneration.
Please send an email to Dedra Jeffries (email@example.com) if you are interested in the seminar.