Translational Control of Cardiac Disease
Heart disease is the most significant cause of morbidity and mortality worldwide. Better understanding of the pathological mechanisms underlying heart disease will improve preventive and therapeutic interventions. Our laboratory is interested in deciphering pathophysiological function and molecular mechanism of translational control mediated by regulatory non-coding RNAs or RNA-binding proteins in heart disease. Here I will discuss our recent research advances in two ongoing projects: 1) miR-574-FAM210A axis regulates mitochondrial translation and cardiac remodeling; 2) EPRS regulates Pro-rich profibrotic protein translation in cardiac fibrosis.