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The Department of Physiology Seminar with Assistant Professor Candidate Dr. Humberto Joca Thursday, February 24, 2022 at 1:00 PM

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Date:

Thursday, February 24, 2022

Time:

1:00 PM

Assistant Professor Candidate:

Dr. Humberto Joca, PhD

Research Associate

Center for Biomedical Engineering and Technology

The University of Maryland School of Medicine

Baltimore, Maryland

Title:

Microtubule Mechanotransduction in Striated Muscle

Abstract:

A novel mechanotransduction pathway where mechanical stress is transmitted via the microtubule (MT) network to activate NOX2-dependent ROS signals in heart, skeletal muscle, and other tissues. MTs tune cytoskeletal stiffness, which affects cytoskeletal mechanics and that mechanotransduction signaling of striated muscle. Under normal conditions, these signals act to induce Ca2+ release. Microtubules tune cytoskeletal stiffness, which affects cytoskeletal mechanics and mechanotransduction of striated muscle.  In pathological conditions, such as Duchenne muscular dystrophy (DMD), alterations in the MT network (increased MT density and level of detyrosinated tubulin) stretch elicited abnormal ROS and Ca2+ signals that trigger arrhythmogenic events and facilitate muscle injury. While evidence suggests that microtubules enriched in detyrosinated tubulin regulate these processes in the possible contribution from several other tubulin modifications was lacking. Our most recent work dissects the contribution of MT acetylation to the regulation of cytoskeletal stiffness and mechano-activated ROS and Ca2+ signaling in healthy and dystrophic skeletal muscle and heart, adding to growing evidence that MTs contribute to the mechanobiology of striated muscle.

Please send an email to Dedra Jeffries (djeffri1@uthsc.edu) if you are interested in the seminar.