Join us for the Strategic Planning Town Hall in person in the General Education Building, room A102 or on Zoom on Friday, March 31 at 12:00pm CDT. For those joining in person, enjoy lunch on us before the event at 11:30 am! Links to register for In-Person and Zoom attendance are located on the announcements page.
Neuroscience Institute welcomes: Christoph Kellendonk, PhD.
Associate Professor Department of Psychiatry Department of Molecular Pharmacology & Therapeutics New York State Psychiatric Unit Columbia University “Dopamine D2 receptors and striatal circuit function” Tuesday, March 28, 2023 – 12:00 pm Zoom:https://tennesseehipaa.zoom.us/j/98460101974?pwd=NGVCNHZtUTVNVTk4cE0rU0VRbytmZz09
Meeting ID 984 6010 1974 Passcode 456163
The University of Tennessee is conducting the Annual Verification of Space Inventory during the period of March 27th through May 12th. The Office of Space Planning and Utilization conducts an Annual Space Survey to update and maintain the University’s Space Database.
You are highly encouraged to register for the ZOOM Training Session through K@TE at the link below:
Dr. Chalet Tan will present ” Enhancement of Innate Immunity by an Immunostimulatory Supplement. As one of popular dietary supplements, the health benefits of Arthrospira platensis (commonly known as spirulina) have been broadly reported. Immulina is a commercially available extract of Arthrospira platensis that is enriched with bacterial lipoproteins and acts as a Toll-like receptor 2 (TLR2) agonist. However, the immunostimulatory effect of Immulina in vivo has not been well understood. In this work, we explored the nanoformulation of Immulina to improve the dissolution in aqueous media. Building upon a standardized cell-based assay that measures the bioactivity of Immulina as a TLR2 agonist, we developed a quantitative methodology to determine the Immulina concentration. Immulina-induced proinflammatory responses were studied in mouse bone marrow-derived dendritic cells and macrophages. Finally, the immunological effect of Immulina was investigated in healthy mice following daily oral gavage of Immulina nanosuspension for 6 weeks. Mouse whole blood was sampled weekly and incubated with FITC-labeled E. coli particles, to evaluate the phagocytic activity of the circulating neutrophils by flow cytometry analysis. We found that Immulina significantly increased the phagocytic activity of peripheral neutrophils, suggesting an important mechanism for Immulina to boost innate immunity.