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Department of Prevention Medicine Biostatistics Seminar Series:: Quality control of GWAS summary statistics


The Division of Biostatistics at the Department of Preventive Medicine, UTHSC, invites you to attend the following seminar.  

Time: Monday, February 12, 10:00 AM-11:00 AM CST   

ZOOM Virtual Room Connection: Register in advance for this meeting     

Seminar Website: https://www.eventcreate.com/e/biostatisticsseminar    

Speaker Biohttps://privefl.github.io/


Quality control of GWAS summary statistics

Florian Privé, Ph.D.

National Centre for Register-based Research, Aarhus University, Denmark

Results from genome-wide association studies (GWAS summary statistics) have been extensively used in different applications such as estimating the genetic architecture of complex traits and diseases, identifying causal variants with fine-mapping, and predicting complex traits with polygenic scores. One reason behind the popularity of GWAS summary statistics is that they are widely available and shared, e.g. in the GWAS Catalog. However, these GWAS summary statistics come with varying degrees of quality, and from many different tools and studies. In this presentation, I go over several different cases that could go wrong when using GWAS summary statistics and what we can do about it. Most of these are still unknown to many people using GWAS summary statistics on a regular basis, which can cause results they derive to be biased or suboptimal. I present and discuss past and current work on how to perform some quality control and ultimately improve the quality of GWAS summary statistics, in order to make best use of them.