The Department of Physiology welcomes Dr. Tahir Hussain, Associate Dean for Research and Graduate Programs, Professor of Pharmacology at the University of Houston College of Pharmacy. His seminar titled “Angiotensin AT2 Receptor as a Immunomodulatory and Renoprotective Target” scheduled for Thursday, November 18th, at 3:30pm. Angiotensin type 2 receptor (AT2R) is a component of the protective arm of the renin angiotensin system. Unlike GPCRs, the crystal structure and pharmacological studies suggest that AT2R in response to prolonged agonist exposure is not desensitized or endocytosed. Pharmacological and genetic studies suggested AT2R promotes natriuresis, is anti-inflammatory and protects against kidney injury and hypertension. Specifically, we have shown that AT2R activation reduces kidney injury in obesity, and sodium- and LPS-animal models. These protective functions of AT2R are likely mediated via changes in macrophage phenotype from M1 to M2 and T cell modulation to Treg and their interplay with kidney epithelial cells. AT2R-mediated stimulation of NO/IL-10 presents as a potential molecular pathway for this protective process.
Please contact Miranda Smith (msmit294) for Zoom call-in particulars.
We look forward to seeing everyone Thursday afternoon!