The Department of Physiology welcomes Dr. Zhiyong Lin, Associate Professor of Medicine in the Division of Cardiology, Department of Medicine, at Emory University School of Medicine in Atlanta, Georgia. Dr. Lin is a candidate for the Tenure Track Associate/Full Professor position in the Department of Physiology. Dr. Lin will present a Zoom seminar entitled “Role of matricellular protein CCN3 in vascular pathology” this Friday, December 18, at 12 noon as part of his interview process.
The principal focus of Dr. Lin’s laboratory is the fundamental understanding of the development and progression of cardiovascular diseases at the molecular level. One major research area aims to dissect the roles of a group of matricellular signaling proteins termed CCNs (Cellular Communication Network) in cardiovascular biology. These matricellular proteins interact with growth factors, the extracellular matrix (ECM), cell surface integrins and other receptors to promote ECM-intracellular signaling. Today’s talk focuses on CCN3 and its role within the vasculature. Our work over the past several years has led to the appreciation that CCN3 serves as an important regulator of vascular health, highlighted by the observation that systemic loss of CCN3 promotes abdominal aortic aneurysm in a ERK1/2 dependent manner. Our more recent data points toward CCN3 deficiency as a major contributor to endothelial dysfunction and the loss of barrier integrity, both instrumental in driving the pathology of thoracic aortic aneurysm. We have also shown that bone marrow-derived CCN3 is atheroprotective, in part via the regulation of macrophage foam cell formation. Our ongoing work also substantiates the importance of CCN3 in the promotion of angiogenesis and vascular blood flow recovery after hind limb ischemia (HLI) induction. Mechanistic studies suggest that impaired HIF1a signaling and diminished VEGF-induced angiogenesis likely contribute to the loss of functional collateral blood flow in the context of CCN3 deficiency-induced ischemic injury. Taken together, our experimental data strongly support a critical role for CCN3 in vascular homeostasis.
Please contact Dr. Nathan Tipton (ntipton2) if you would like to receive Zoom call-in information.
We look forward to seeing everyone this Friday at noon!