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Biostatistics Seminar Series: Gene‐level association analysis of ordinal traits with functional ordinal logistic regressions (Monday, October 3rd, 2:00 – 3:00 PM CDT)

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The Division of Biostatistics at the Department of Preventive Medicine invites you to attend the following seminar:

Time: Monday, October 3rd, 2:00 – 3:00 PM CDT

ZOOM Virtual Room Connection: https://tennesseehipaa.zoom.us/meeting/register/tJIkd-6qqjkqHdOIG7qEDdm6RLdcO4QI5ThS

Speaker Biohttps://www.uthsc.edu/faculty/profile/?netid=cchiu1

Publication: https://onlinelibrary.wiley.com/doi/full/10.1002/gepi.22451

 

“Genelevel association analysis of ordinal traits with functional ordinal logistic regressions”

Dr. Chi-Yang Chiu,
Biostatistics Division, University of Tennessee Health Science Center

We develop functional ordinal logistic regression (FOLR) models to perform gene‐based analysis of ordinal traits. In the proposed FOLR models, genetic variant data are viewed as stochastic functions of physical positions and the genetic effects are treated as a function of physical positions. The FOLR models are built upon functional data analysis which can be revised to analyze the ordinal traits and high dimension genetic data. The proposed methods are capable of dealing with dense genotype data which is usually encountered in analyzing the next‐generation sequencing data. The methods are flexible and can analyze three types of genetic data: (1) rare variants only, (2) common variants only, and (3) a combination of rare and common variants. Simulation studies show that the likelihood ratio test statistics of the FOLR models control type I errors well and have good power performance. The proposed methods achieve the goals of analyzing ordinal traits directly, reducing high dimensionality of dense genetic variants, being computationally manageable, facilitating model convergence, properly controlling type I errors, and maintaining high power levels. The FOLR models are applied to analyze Age‐Related Eye Disease Study data, in which two genes are found to strongly associate with four ordinal traits.