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Biostatistics Seminar Series: “Association Testing Based On Sequencing Data With Arbitrary Depth” by Dr. Zheng Xu of University of Nebraska-Lincoln, on Monday, October 22 at 2 P.M

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Dear Colleagues,

The Division of Biostatistics at the Department of Preventive Medicine invites you to attend the following seminar by our guest speaker, Dr. Zheng Xu of University of Nebraska-Lincoln.

Date: Monday, October 22, 2018

Time: 2 P.M.

Place: 4th Floor Conference Room 400 in the Doctors Office Building at 66 N. Pauline Street, Memphis, TN 38105. Please park in the multi-story parking garage adjacent to the Doctors Office Building, and bring your parking card with you so we can give you a validation ticket.

ZOOM Virtual Room Connection: If you cannot join us in person, please join us in our virtual conference room at  https://tennessee.zoom.us/j/476519327.

Presenter: Zheng Xu fPh.D., Research Assistant Professor, Department of Statistics,  University of Nebraska-Lincoln.

Title: Association Testing Based On Sequencing Data With Arbitrary Depth

Abstract: Association studies have been widely conducted to explain the relationship between phenotypes and genetic variants. Researchers have been developed association testing methods for a single marker or a group of markers based on genotypes. The phenotypes, either continuous or binary traits, are studied in the regression framework with genotypes as explanatory variables. Some factors such as genotype calling uncertainty and sequencing depth may influence the performance of these genotype-based testing methods. We propose association testing methods directly based on next-generation sequencing data without genotype calling. The methods have been applied to the testing for a single marker or a group of markers with applications to rare variants.

We look forward to seeing you all among us.

Mehmet Kocak, Ph.D.

Associate Professor of Biostatistics

Department of Preventive Medicine, UTHSC