The Look AHEAD (Action for Health in Diabetes) Study, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), began in 2001 to examine whether weight loss and increased physical activity would prevent cardiovascular events in those with type 2 diabetes. [Read more...]
Karen C. Johnson, MD, MPH, Interim Chair of the Department of Preventive Medicine at UTHSC, Awarded $1.6 Million to Continue Observational Phase of Look AHEAD Study
It is well known that patients with Alzheimer’s and other disorders, such as type 2 diabetes, develop amyloid, a substance composed of sticky protein fibers and sugar molecules that builds up in the brain or other organs in the body. Doctors do not know whether this material causes the diseases, or whether the diseases lead to amyloid formation. However, in less common diseases, such as light chain amyloidosis, a rare but devastating illness caused by the aggregation of antibody-related light chain proteins in organs such as the heart, liver, kidneys and spleen, there is no doubt that amyloid presence in the organs is the cause of the disease. [Read more...]
Associate Professor Joanna Q. Hudson of UTHSC Receives $140,000 Grant to Research Antibiotic Dosing For Patients Undergoing a New Method of Dialysis
Seriously ill patients who develop bacterial infections in the bloodstream require aggressive treatment with antibiotics. They also can develop kidney failure that requires hemodialysis.
Professor Linda Nichols of UTHSC Awarded $597,313 Grant to Study Whether Dementia Caregiver Interventions Reduce Health Care Costs
In the United States, nearly 11 million caregivers provide 12.5 billion hours of care annually to those with Alzheimer’s disease, according to Linda Nichols, PhD, professor of Preventive Medicine and Internal Medicine at the University of Tennessee Health Science Center (UTHSC). [Read more...]
According to experts, breast cancer is a leading cause of cancer-related deaths in women worldwide. Among breast cancer patients, those diagnosed with triple-negative breast cancer (TNBC), an aggressive breast cancer subtype, have a lower survival rate, in part because there is a lack of effective targeted therapy.
Chemotherapy is the only available systemic treatment for TNBC. However, many TNBC patients rapidly develop resistance to the treatments. They also develop aggressive metastasis, which is responsible for the majority of the deaths caused by the cancer. Zhaohui Wu, MD, PhD, is exploring other options that could lead to a breakthrough in treatment. [Read more...]
Robert W. Williams, PhD, professor in the Departments of Anatomy and Neurobiology, and Pediatrics at the University of Tennessee Health Science Center (UTHSC) and director of the UT Center for Integrative and Translational Genomics, aims to make significant headway in studying the genetics of diet and aging, thanks to a new grant. The award, from the National Institute on Aging, a subsidiary of the National Institutes of Health (NIH), totals $2,545,349. It will fund his five-year study entitled, “Translational Systems Genetics of Mitochondria, Metabolism, and Aging.” [Read more...]
Tuberculosis (TB) is an infectious disease that is often contracted through an airborne bacterium known as Mycobacterium tuberculosis. It remains a leading public health problem worldwide, with an estimated 8 million new cases and 2 million deaths each year. Although most M. tuberculosis infections, known as pulmonary TB, are in the lungs, 5 to 10 percent of TB patients can develop the disease in organs other than their lungs, or extrapulmonary TB. Ying Kong, PhD, is exploring the pathogenesis or the origin and development of the latter. [Read more...]
UTHSC Assistant Professor Catherine Kaczorowski Brings $737,720 Grant to Memphis to Continue Alzheimer’s Research
As the population ages, Alzheimer’s disease is a major public health concern in the United States. An estimated 11 million to 16 million elderly will suffer from the disease by 2050. Aging is the most important risk factor for Alzheimer’s disease, but it is not clear to what extent the molecular changes that underlie normal age-associated memory deficits contribute to dementia in Alzheimer’s disease. Catherine Kaczorowski, PhD, is exploring this concept. [Read more...]