Karen C. Johnson, MD, MPH, Interim Chair of the Department of Preventive Medicine at UTHSC, Awarded $1.6 Million to Continue Observational Phase of Look AHEAD Study

Dr. Karen C. Johnson is the principal investigator for the Look AHEAD Study at UTHSC.

Dr. Karen C. Johnson is the principal investigator for the Look AHEAD Study at UTHSC.

The Look AHEAD (Action for Health in Diabetes) Study, funded by the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), began in 2001 to examine whether weight loss and increased physical activity would prevent cardiovascular events in those with type 2 diabetes. [Read more...]

Professor Jonathan Wall Receives $1.58 Million Grant for Amyloid Disease Research

Dr. Jonathan Wall is exploring diagnostic and therapeutic agents for amyloid diseases. Dr. Wall has identified p5, a protein that binds to amyloid in the brain and other organs, making the amyloid visible through PET imaging and other techniques.

Dr. Jonathan Wall is exploring diagnostic and therapeutic agents for amyloid diseases. Dr. Wall has identified p5, a protein that binds to amyloid in the brain and other organs, making the amyloid visible through PET imaging and other techniques.

It is well known that patients with Alzheimer’s and other disorders, such as type 2 diabetes, develop amyloid, a substance composed of sticky protein fibers and sugar molecules that builds up in the brain or other organs in the body. Doctors do not know whether this material causes the diseases, or whether the diseases lead to amyloid formation. However, in less common diseases, such as light chain amyloidosis, a rare but devastating illness caused by the aggregation of antibody-related light chain proteins in organs such as the heart, liver, kidneys and spleen, there is no doubt that amyloid presence in the organs is the cause of the disease. [Read more...]

Associate Professor Joanna Q. Hudson of UTHSC Receives $140,000 Grant to Research Antibiotic Dosing For Patients Undergoing a New Method of Dialysis

Elvira Gosmanova, MD, left, and Joanna Q. Hudson, PharmD, will use a $140,000 grant from the Oxnard Foundation to study antibiotic dosing for patients undergoing Sustained Low Efficiency Dialysis.

Elvira Gosmanova, MD, left, and Joanna Q. Hudson, PharmD, will use a $140,000 grant from the Oxnard Foundation to study antibiotic dosing for patients undergoing Sustained Low Efficiency Dialysis.

Seriously ill patients who develop bacterial infections in the bloodstream require aggressive treatment with antibiotics. They also can develop kidney failure that requires hemodialysis.

[Read more...]

Professor Linda Nichols of UTHSC Awarded $597,313 Grant to Study Whether Dementia Caregiver Interventions Reduce Health Care Costs

(From left) Jennifer Martindale-Adams, EdD; Teresa Waters, PhD; and Linda Nichols, PhD, will examine data from previous studies to see if caregiver interventions reduce health care costs. Not pictured, is co-investigator, Robert Burns, MD.

(From left) Jennifer Martindale-Adams, EdD; Teresa Waters, PhD; and Linda Nichols, PhD, will examine data from previous studies to see if caregiver interventions reduce health care costs. Not pictured, is co-investigator, Robert Burns, MD.

In the United States, nearly 11 million caregivers provide 12.5 billion hours of care annually to those with Alzheimer’s disease, according to Linda Nichols, PhD, professor of Preventive Medicine and Internal Medicine at the University of Tennessee Health Science Center (UTHSC). [Read more...]

Assistant Professor Zhaohui Wu of UTHSC Receives $720,000 Grant for Breast Cancer Research

The American Cancer Society has awarded $720,000 to Dr. Zhaohui Wu to continue his studies of treatment options for triple-negative breast cancer.

The American Cancer Society has awarded $720,000 to Dr. Zhaohui Wu to continue his studies of treatment options for triple-negative breast cancer.

According to experts, breast cancer is a leading cause of cancer-related deaths in women worldwide. Among breast cancer patients, those diagnosed with triple-negative breast cancer (TNBC), an aggressive breast cancer subtype, have a lower survival rate, in part because there is a lack of effective targeted therapy.

Chemotherapy is the only available systemic treatment for TNBC. However, many TNBC patients rapidly develop resistance to the treatments. They also develop aggressive metastasis, which is responsible for the majority of the deaths caused by the cancer. Zhaohui Wu, MD, PhD, is exploring other options that could lead to a breakthrough in treatment. [Read more...]

Professor Robert W. Williams of UTHSC Receives More Than $2.5 Million for Genetics Research

Dr. Robert Williams and his research team have received a more than $2.5 million grant to study the genetics of diet and aging.

Dr. Robert Williams and his research team have received a more than $2.5 million grant to study the genetics of diet and aging.

Robert W. Williams, PhD, professor in the Departments of Anatomy and Neurobiology, and Pediatrics at the University of Tennessee Health Science Center (UTHSC) and director of the UT Center for Integrative and Translational Genomics, aims to make significant headway in studying  the genetics of diet and aging, thanks to a new grant. The award, from the National Institute on Aging, a subsidiary of the National Institutes of Health (NIH), totals $2,545,349. It will fund his five-year study entitled, “Translational Systems Genetics of Mitochondria, Metabolism, and Aging.” [Read more...]

Assistant Professor Ying Kong of UTHSC Receives $187,343 Grant to Continue Tuberculosis Research

With his new grant funding, Dr. Ying Kong will delve deeper into his studies of tuberculosis, primarily focusing on host-pathogen interactions.

With his new grant funding, Dr. Ying Kong will delve deeper into his studies of tuberculosis, primarily focusing on host-pathogen interactions.

Tuberculosis (TB) is an infectious disease that is often contracted through an airborne bacterium known as Mycobacterium tuberculosis. It remains a leading public health problem worldwide, with an estimated 8 million new cases and 2 million deaths each year. Although most M. tuberculosis infections, known as pulmonary TB, are in the lungs, 5 to 10 percent of TB patients can develop the disease in organs other than their lungs, or extrapulmonary TB. Ying Kong, PhD, is exploring the pathogenesis or the origin and development of the latter. [Read more...]

UTHSC Assistant Professor Catherine Kaczorowski Brings $737,720 Grant to Memphis to Continue Alzheimer’s Research

Catherine Kaczorowski, PhD, brings a $737,720 grant to Memphis to continue her research of Alzheimer’s disease.

Catherine Kaczorowski, PhD, brings a $737,720 grant to Memphis to continue her research of Alzheimer’s disease.

As the population ages, Alzheimer’s disease is a major public health concern in the United States. An estimated 11 million to 16 million elderly will suffer from the disease by 2050. Aging is the most important risk factor for Alzheimer’s disease, but it is not clear to what extent the molecular changes that underlie normal age-associated memory deficits contribute to dementia in Alzheimer’s disease. Catherine Kaczorowski, PhD, is exploring this concept. [Read more...]